Lab presentation

Diversity, regulation and signalling function of amino-acid transporters in yeast and human cells

Amino acid transporters play a crucial metabolic role in all cells and their dysfunction is at the origin of various diseases. Our main interest is to understand the molecular mechanisms involved in the physiological regulation of these proteins. We also study the ability of amino acid transporters to control signaling. Our main cellular model is the yeast S. cerevisiae and more recent work has been extended to human cells. We currently investigate amino acid transporters present at the plasma membrane and others located at the lysosomal membrane.

On-going projects of the lab are concerned with :

– Mechanisms and signals inducing ubiquitylation and endocytosis of amino acid transporters
– Cystinosis, a genetic disease caused by dysfunction of cystine transport across the lysosomal membrane
Function and regulation of amino acid transporters : insights from predicted structure
– Study of an amino acid transporter that lost its transport activity and evolved into a sensor of external amino acids
– Mechanisms of amino acid excretion by yeast cells and its industrial applications