Lab presentation

Diversity, regulation and signalling function of plasma membrane and lysosomal transporters in yeast and human cells

Membrane transporters play a crucial metabolic role in all cells and their dysfunction is at the origin of various diseases. Our main interest is to understand the molecular mechanisms involved in the physiological regulation of these proteins. We also study the ability of transporters to control signaling. Our main cellular model is the yeast S. cerevisiae and more recent work has been extended to human cells. 

One of our main current interests is to better understand the functional links between membrane transporters and the TOR kinase complex 1 (TORC1) controlling cellular growth and that is very often dysregulated in cancer cells.

On-going projects of the lab are concerned with :

– Role of the plasma membrane H+-ATPase in TORC1 control
– Study of a novel TORC1 activation pathway responding to key nutritional meabolites 
– Study of vacuolar amino acid transporters and their relationships with TORC1
– Amino acid excretion by yeast : mechanisms and industrial applications
– Role of TORC1 in ubiquitylation and endocytosis of amino acid transporters