Regulation and role in signalling of plasma membrane and lysosomal transporters in yeast and more complex cells
Membrane transporters play a crucial metabolic role in all cells and their dysfunction causes diverse diseases. Our main interest is to understand the molecular mechanisms involved in the physiological regulation of these proteins. We also study the ability of transporters to trigger signaling. Our cellular model is the yeast S. cerevisiae and we extended some of our studies to human and plant cells.
Our main current interests are the lysosomal membrane transporters, their impact on cell aging, and their relationships with the TOR kinase complex 1 (TORC1) that controls cellular growth and that is often deregulated in cancer cells.