Meeting and seminar at de Duve Institute

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Elie Saliba was invited to present his work at the one-day STUNNING (Structure and Function in Signaling) meeting of the SFMBBM doctoral school of the FRS-FNRS, that has been organized on November 18 at the de Duve institute (Woluwe, Brussels) by PhD students. At the end of the meeting, Elie’s talk was elected by participants as the 2nd best presentation by a PhD student. A few days before, B. André was invited at the de Duve Institute to give a seminar about the “Lateral segregation, ubiquitylation and endocytosis of amino acid transporters in yeast”.

Congratulations to Dr. Ohsumi

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We are delighted to congratulate Dr. Yoshinori Ohsumi on being awarded the 2016 Nobel Prize in Physiology or Medicine, for his superb work on the genetic and biochemical dissection of autophagy in the model yeast Saccharomyces cerevisiae. See the very interesting interview of Dr. Ohsumi published in 2012 by The Journal of Cell Biology.

“Smyte” meeting in Crete

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C. Gournas and B. André attended the 34th “Small Meeting on Yeast Transport and Energetics” (Smyte) which was organized by our colleague George Diallinas in Crete (August 29 – September 1). The Smyte annually gathers scientists from all countries who are interested in diverse aspects yeast membrane transporters: structure-function relationships, regulation of intracellular traffic, signalling properties, … B. André was invited to present the opening “Marcelle Grenson Lecture” of the meeting, and C. Gournas gave a presentation on the lateral segregation of the yeast arginine permease, Can1, at the plasma membrane. We all enjoyed the top-quality science presented at the meeting … as well as the many nice aspects of life in Crete, including a memorable music concert by Ross Daly & Kelly Thoma. See also the Facebook page of the meeting.

Novel study on the structural dynamics of an arginine transporter published

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A novel collaborative study by Eva-Maria Krammer, Kassem Ghaddar, Bruno André and Martine Prévost was just published in PLoS One. The article entitled “Unveiling the Mechanism of Arginine Transport through AdiC with Molecular Dynamics Simulations: The Guiding Role of Aromatic Residuesreports the data obtained by molecular dynamics simulation methods unraveling the molecular details of arginine transport through the bacterial AdiC transporter. Have a look to the movie illustrating the molecular dynamics of the AdiC transporter. The conformational changes adopted by a transporter during transport catalysis are of high interest also in the context of yeast and human cells as they are thought to promote interactions with cytosolic factors involved in ubiquitylation and signaling.

“Lysosomes and Endocytosis” Gordon conference in Boston

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Thanks to the support of the FNRS and the Brachet Foundation, Céline Barthélemy and Christos Gournas attended  the “Lysosomes and Endocytosis” Gordon conference (June 12-17) which was held in Andover, near Boston (USA). This meeting is one of the most renownded about the molecular mechanisms and functions of endocytosis and the endosomal and lysosomal pathways. Céline presented a poster about the endocytosis of the human LAT1 amino acid transporter in HeLa cells, and Christos presented one about the role of arrestins and structural changes in ubiquitylation and endocytosis of the yeast arginine permease, Can1.

Yeasterday meeting at Leuven

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Elie Saliba and Bruno André attended the one-day Yeasterday meeting (May 13), which was organized in Leuven by our colleagues J. Winderickx, K. Verstrepen, and P. Van Dijck. The Yeasterday meeting gathers the research groups of the Benelux working on yeast as a model system.

LMO meeting (Brussels)

DSC_0029Almost all lab members attended the “12th Levures, modèles et outils (LMO)” meeting organized in Brussels. Sir Paul Nurse (Nobel prize 2001) was among the speakers. Melody Cools and Céline Barthelemy, among several other young researchers, were invited to give oral presentations.

 

Spring Biopark News

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“Cystinosis Research Foundation” symposium

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Melody Cools and Bruno André attended to the last scientific symposium organized by the “Cystinosis Research Foundation” (Irvine, USA, March 3-4). The meeting gathered all the research groups supported by the CRF and conducting fundamental or clinical research studies on cystinosis, a rare genetic disease caused by mutations in the CTNS gene. This gene encodes a transporter present at the lysosomal membrane and catalyzing export to the cytosol of cystine, the compound made of two cysteines linked by a disulfide bridge. The keynote speaker at the symposium was Dr. Hal Hoffman, a world renowned expert in the field of inflammation.

“Yeast Membrane Transport” book published

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A novel review entitled “Function and Regulation of Fungal Amino Acid Transporters: Insights from Predicted Structure” by Gournas C, Kramer M-E, Prévost M & B André has just been published in a Springer book “Yeast Membrane Transport” edited by Ramos, Sychrova and Kschischo, and also appears in “Advances in Experimental Medicine and Biology”.