Novel ubiquitylation pathway for Gap1 permease published in JBC

The editors of the Journal of Biological Chemistry informed us that our last paper entitled “Stress conditions promote yeast Gap1 permease  ubiquitylation and downregulation via the arrestin-like Bul and Aly proteins” has been accepted for publication. This work, carried out by Myriam Crapeau and Ahmad Merhi, shows that inhibition of the TORC1 kinase complex, or any stress condition, stimulates ubiquitylation and endocytosis of the yeast Gap1 permease via a mechanism different from the one we previously described for the amino-acid induced Gap1 downregulation (Merhi and André, 2012).